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Magnetic Nanoprobes for Spatio-Mechanical Manipulation in Single Cells
Iuliia P. Novoselova, Andreas Neusch, Julia-Sarita Brand, Marius Otten, Mohammad Reza Safari, Nina Bartels, Matthias Karg, Michael Farle, Ulf Wiedwald and Cornelia Monzel:
Nanomaterials, 11, 9, 2267 (2021)
doi: 10.3390/nano11092267





Magnetic nanoparticles (MNPs) are widely known as valuable agents for biomedical applications. Recently, MNPs were further suggested to be used for a remote and non-invasive manipulation, where their spatial redistribution or force response in a magnetic field provides a fine-tunable stimulus to a cell. Here, we investigated the properties of two different MNPs and assessed their suitability for spatio-mechanical manipulations: semisynthetic magnetoferritin nanoparticles and fully synthetic ‘nanoflower’-shaped iron oxide nanoparticles. As well as confirming their monodispersity in terms of structure, surface potential, and magnetic response, we monitored the MNP performance in a living cell environment using fluorescence microscopy and asserted their biocompatibility. We then demonstrated facilitated spatial redistribution of magnetoferritin compared to ‘nanoflower’-NPs after microinjection, and a higher magnetic force response of these NPs compared to magnetoferritin inside a cell. Our remote manipulation assays present these tailored magnetic materials as suitable agents for applications in magnetogenetics, biomedicine, or nanomaterial research.

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